Hello, this is Ilwon Station Exit 1 Pharmacy.
I will tell you about Pfizer's Sibinco.
For those suffering from atopic dermatitis, Sibinco (Abrocitinib) is an oral JAK inhibitor that effectively reduces itching and inflammation.
Samsung Seoul Hospital also prescribes it to patients,
and it has the advantage of being convenient to take compared to existing treatments.
In this article, I will accurately organize the dosage, efficacy, mechanism of action, side effects, and precautions of Sibinco.
What is Sibinco? (Abrocitinib)
Oral JAK inhibitor containing abrocitinib
Treatment of moderate to severe atopic dermatitis
Prescribed to adolescents and adults aged 12 years or older
Convenient to take in pill form, not injection
Sibinco tablet dosage
- Adults: 200 mg once a day (can be adjusted to 100 mg if necessary)
- Adolescents (12-17 years old) or 65 years or older: Start with 100 mg
- Can be taken regardless of meals
- Recommended to take at the same time (maximize effect if made a habit)
- If you miss the time of taking
- Within 12 hours: Take immediately
- More than 12 hours: Take according to the next schedule
Sibinco tablet efficacy and effects
- Itching relief effect begins within 24 hours of taking
- Skin improvement in more than 50% of patients after 12 weeks of taking
Main effects
- Relief of skin rash and redness
- Reduction of itching and inflammation
- Restoration of skin barrier function
- Improvement of symptoms that interfere with sleep
Source: Seoul Asan Medical Center
 |
| ref. Seoul Asan Hospital |
Mechanism of action of Sibinko
Sibinko blocks JAK1 protein and suppresses inflammatory signals (IL-4, IL-13, IL-31, etc.).
In simple terms, it acts as a switch that blocks the wrong signal of "itching" in the body.
Sibinko Pharmacokinetics (process of drug action in the body)
- Blood concentration reaches maximum within 1 hour after administration
- Half is excreted from the body within 3-5 hours
- Metabolized in the liver and excreted through urine and feces
Sibinko Side effects and precautions
All drugs can have side effects, but most are mild and relieved after the body adapts.
Common side effects (temporary symptoms)
- Nausea
- Headache
- Acne
Rare but important side effects
- Increased risk of infection (watch out for colds, shingles)
- Changes in blood counts (anemia, decreased white blood cells)
- Very rare cases of blood clot risk reported
Precautions when taking Sibinco
- Do not take during pregnancy or breastfeeding (may affect fetus and baby)
- Infection prevention is necessary (be careful of immunosuppressive effects)
- Consultation with a doctor is essential when taking with other medications (especially anticoagulants, contraceptives, etc.)
- Regular checkups are essential (check liver function and blood counts)
Advice for atopic patients and their families
Atopic dermatitis is not a simple skin disease, but a disease that affects the quality of life. It is most effective to combine drug treatment and lifestyle management.
Lifestyle habits for improving atopic dermatitis
- Use moisturizer more than twice a day
- Stress management and improved sleep
- Reduce irritating foods (spicy foods, alcohol, etc.)
- Avoid fine dust and dry environments
Frequently Asked Questions (FAQ)
Q1. Can Sibincojeong be purchased without a prescription?
A. No. A doctor's prescription is required.
Q2. Can it be used with steroid ointment?
A. It can be used concurrently if necessary, but it must be decided after consulting a doctor.
Q3. When will the effects appear after taking it?
A. Improvement is observed within 24 hours at the earliest, and usually after 2-4 weeks.
Q4. Is it okay to take Sibincojeong for a long period of time?
A. You can take it for a long period of time while receiving regular checkups.
Ilwon Station Exit 1 Pharmacy
provides fast and accurate preparation, and friendly and professional consultation.
Location: Seoul, South Korea. Subway Line 3, Ilwon Station, Basement M
Inquiries: 02-445-1011
